|
T1817 |
GNF-2
|
GNF2 |
SARS-CoV
,
Bcr-Abl
|
|
GNF-2 is a highly selective non-ATP competitive inhibitor of Bcr-Abl. |
|
T6223 |
U0126-EtOH
|
U0126 Ethanol,U0126 |
Mitophagy
,
Influenza Virus
,
MEK
,
Autophagy
|
|
U0126-EtOH (U0126 Ethanol) is a non-ATP competitive specific inhibitor of MEK1/2 (IC50: 0.07/0.06 μM). |
|
T10898 |
Samuraciclib hydrochloride
|
ICEC0942 hydrochloride,CT7001 hydrochloride |
Apoptosis
,
CDK
|
|
Samuraciclib hydrochloride (ICEC0942 hydrochloride) is a potent, selective, ATP competitive and oral active CDK7 inhibitor with IC50 of 41 nM. The selectivity of Samuraciclib hydrochloride is 45-, 15-, 230- and 30-fold h... |
|
T8685 |
SP-146
|
|
Aurora Kinase
|
|
SP-146 is a selective, potent and non-ATP-competitive Aurora B inhibitor(IC50 : 0.316 nM). |
|
T14988 |
CMPD1
|
|
MAPK
|
|
CMPD1 is a non-ATP-competitive p38 MAPK-mediated MK2 phosphorylation inhibitor(apparent Ki (Kiapp): 330 nM). |
|
T6546 |
IPA-3
|
IPA3,IPA 3 |
PAK
|
|
|
|
T6083 |
AZD8330
|
ARRY-424704,ARRY-704 |
ERK
,
MEK
|
|
AZD8330 (ARRY-704) is a novel, selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 nM. Phase 1. |
|
T16560 |
Poloxin
|
|
PLK
|
|
Poloxin is a non-ATP competitive Polo-like Kinase 1 inhibitor. It targets the polo-box domain (IC50: appr 4.8 μM). |
|
T6636 |
Refametinib
|
BAY 86-97661,BAY 869766,RDEA119 |
MEK
|
|
Refametinib (RDEA119) (RDEA119, Bay 86-9766) is an effective, ATP non-competitive and specific inhibitor of MEK1/2 (IC50: 19/47 nM). |
|
T2443 |
CI-1040
|
PD 184352 |
Apoptosis
,
MEK
|
|
CI-1040 (PD 184352) (PD184352) is an ATP non-competitive MEK1/2 inhibitor (IC50: 17 nM). |
|
T2125 |
Trametinib
|
GSK1120212,JTP-74057 |
Apoptosis
,
MEK
,
Autophagy
|
|
Trametinib (GSK1120212) is a MEK inhibitor that inhibits MEK1 and MEK2 (IC50=0.7/0.9 nM) with ATP non-competitive and oral activity. Trametinib activates autophagy and induces apoptosis. |
|
T6152 |
PD318088
|
|
MEK
|
|
PD318088 is a non-ATP competitive allosteric MEK1/2 inhibitor, binding simultaneously with ATP in a region of the MEK1 active site that is adjacent to the ATP-binding site. |
|
T3067 |
Tideglusib
|
NP-12,NP031112 |
GSK-3
|
|
Tideglusib (NP031112), a non-ATP competitive inhibitor of glycogen synthase kinase 3 (GSK-3), is with anti-inflammatory and neuroprotective activities. |
|
T1803 |
GNF-5
|
GNF 5 |
SARS-CoV
,
Bcr-Abl
|
|
GNF-5 is a specific non-ATP competitive inhibitor of Bcr-Abl (IC50: 0.22±0.1 uM, Wild-type Abl). It is an analog of GNF-2 with improved pharmacokinetic properties. |
|
T4442 |
MK2-IN-1 hydrochloride
|
MK2 Inhibitor,MK 25 |
MAPK
|
|
MK2-IN-1 hydrochloride (MK 25) is a highly selective, non-ATP competitive inhibitor of p38/mitogen-activated protein kinase-activated protein kinase 2 (MAPKAPK2 or MK2, IC50: 0.11 μM) [1]. |
|
T73331 |
GSK3-IN-3
|
|
Mitophagy
,
GSK-3
|
|
GSK3-IN-3 is a mitochondrial autophagy (mitophagy) inducer and GSK-3 inhibitor (IC50: 3.01 μM) that induces parkin-dependent mitochondrial autophagy. GSK3-IN-3 is non-ATP and non-substrate competitive and neuroprotective... |
|
T2623 |
PD98059
|
PD 98059 |
ERK
,
Aryl Hydrocarbon Receptor
,
MEK
,
Autophagy
|
|
PD98059 is an MEK inhibitor that inhibits MEK1 and MEK2 (IC50=2/50 μM) and is non-ATP-competitive. PD98059 is also antagonistic as a ligand for AHR. PD98059 inhibits autophagy. |
|
T6189 |
Mirdametinib
|
PD325901,PD0325901 |
Apoptosis
,
MEK
,
Autophagy
|
|
Mirdametinib (PD325901) is an MEK inhibitor (IC50=0.33 nM) with selective, non-ATP-competitive, and oral activity. Mirdametinib exhibits antitumor activity by inhibiting p-ERK1/2 expression and inducing apoptosis. |
|
T73269 |
CK2α-IN-1
|
|
Casein Kinase
|
|
CK2α-IN-1 is a selective non-ATP-competitive CK2α inhibitor with an IC50 of 7.0 µM and a Ki of 1.6 µM.CK2α-IN-1 exhibits potential anticancer activity and can be used in cancer research. |
|
T4398 |
LX2343
|
|
Beta Amyloid
,
Beta-Secretase
,
BACE
,
PI3K
,
Autophagy
|
|
LX2343 is a BACE1 enzyme inhibitor with an IC50 value of 11.43±0.36 μM. LX2343 acts as a non-ATP competitive PI3K inhibitor with an IC50 of 15.99±3.23 μM. LX2343 stimulates autophagy in its promotion of Aβ clearance. |
|
T5818 |
Rigosertib sodium
|
Rigosertib,Estybon,ON-01910 |
Apoptosis
,
PLK
,
PI3K
|
|
Rigosertib sodium (ON-01910), a non-ATP-competitive inhibitor of PLK1(IC50=9 nM), exhibits 30-fold higher specificity activity over Plk2 and no effect on Plk3. |
|
T6673 |
SKI II
|
SphK-I2 |
Apoptosis
,
Wnt/beta-catenin
,
S1P Receptor
|
|
SKI II (SphK-I2) is a highly selective and non-ATP-competitive S1P receptor inhibitor (IC50: 0.5 μM) while exhibiting no inhibitory action on other kinases including PKCα, PI3K, and ERK2. |
|
T16750 |
Rigosertib
|
ON-01910 |
Apoptosis
,
FLT
,
PLK
,
PI3K
,
Bcr-Abl
,
CDK
,
PDGFR
,
Src
|
|
Rigosertib (ON-01910) is a selective and non-ATP-competitive inhibitor of PLK1 (IC50: 9 nM). Rigosertib is a multi-kinase inhibitor and a selective anti-cancer agent, which induces apoptosis by inhibition of the PI3 kina... |
|
T6070 |
(E/Z)-Rigosertib sodium
|
(E/Z) ON-01910 sodium |
PLK
|
|
ON-01910 is a non-ATP-competitive PLK1 inhibitor(IC50 of 9 nM, in a cell-free assay). It shows 30-fold greater selectivity against Plk2 and no activity to Plk3. Rigosertib inhibits PI3K/Akt pathway and activates oxidativ... |
|
T4391 |
Syk Inhibitor II dihydrochloride
|
Syk Inhibitor II (hydrochloride) |
Others
,
Tyrosine Kinases
,
Syk
,
PKC
,
BTK
|
|
Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that, upon phosphorylation, binds to immunoreceptor tyrosine-based activation motifs of FcRγ chains and mediates downstream signaling related to platelet fun... |
|
T69045 |
ON012380
|
|
|
|
ON012380 is a non-ATP-competitive Bcr-Abl inhibitor, potently inhibiting imatinib-resistant Bcr-Abl mutants such as T315I. |
|
T16559 |
Poloxime
|
|
PLK
|
|
Poloxime is a hydrolysis product of poloxin and is a non-ATP-competitive Plk1 inhibitor. It also has moderate Plk1 inhibitory activity. |
|
T36778 |
MK2-IN-1
|
MK2-IN-1 (MK2 Inhibitor) |
|
|
MK2-IN-1 is a potent and selecitve MAPKAPK2(MK2) inhibitor(IC50=0.11 uM) with a non-ATP competitive binding mode. |
|
T8537 |
Tripolin A
|
|
Aurora Kinase
|
|
Tripolin A is a specific non-ATP competitive inhibitor of Aurora A kinase(Aurora A and Aurora B with IC50 values of 1.5 μM and 7 μM, respectively) |
|
T70152 |
Miransertib mesylate
|
|
|
|
Miransertib mesylate is a selective AKT inhibitor that binds to and inhibits the activity of AKT in a non-ATP competitive manner, which may result in the inhibition of the PI3K/AKT signaling pathway. This may result in r... |
|
T63929 |
Selumetinib sulfate
|
|
|
|
Selumetinib (AZD6244) is a potent, selective, non-ATP-competitive MEK1/2 inhibitor that inhibits MEK1/2 phosphorylation levels with an IC50 value of 14 nM for MEK1. |
|
T61431 |
Topoisomerase IIα-IN-4
|
|
|
|
Topoisomerase IIα-IN-4 (F2) is a non-intercalative ATP-competitive inhibitor of human DNA topoisomerase II, specifically inhibiting TopoIIα with an IC50 value of 3.8 μM and TopoIIβ with an IC50 value of 10.1 μM. It demon... |
|
T62118 |
KIF18A-IN-4
|
|
|
|
KIF18A-IN-4 is a moderately potent non-competitive KIF18A inhibitor of ATP and microtubule with an IC50 of 6.16 μM. KIF18A-IN-4 selectively acts on a large number of mitotic kinesins and kinases, with no direct effect on... |
|
T71556 |
MK-1496
|
|
|
|
MK1496 is a n orally bioavailable Polo-like kinase 1 (Plk1) inhibitor with potential antineoplastic activity. Polo-like kinase 1 inhibitor MK1496 selectively inhibits Plk1, inducing selective G2/M arrest followed by apop... |
|
T12068 |
MK-8033 hydrochloride
|
|
Others
|
|
MK-8033 hydrochloride is an effective and orally active dual inhibitor of ATP competitive c-Met/Ron, with 1 nM for c-Met and 7nM for Ron IC50. MK-8033 hydrochloride has a high affinity for activated kinase conformation, ... |
|
T68459 |
RO4927350
|
|
|
|
RO4927350 is a potent and highly selective non-ATP-competitive MEK1/2 inhibitor. RO4927350 selectively blocks the MAPK pathway signaling both in vitro and in vivo, which results in significant antitumor efficacy in a bro... |
